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On Directional Selectivity in Vertebrate Retina: An Experimental and Computational Study

dc.date.accessioned2004-10-20T19:57:21Z
dc.date.accessioned2018-11-24T10:21:56Z
dc.date.available2004-10-20T19:57:21Z
dc.date.available2018-11-24T10:21:56Z
dc.date.issued1992-01-01en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/6804
dc.identifier.urihttp://repository.aust.edu.ng/xmlui/handle/1721.1/6804
dc.description.abstractThis thesis describes an investigation of retinal directional selectivity. We show intracellular (whole-cell patch) recordings in turtle retina which indicate that this computation occurs prior to the ganglion cell, and we describe a pre-ganglionic circuit model to account for this and other findings which places the non-linear spatio-temporal filter at individual, oriented amacrine cell dendrites. The key non-linearity is provided by interactions between excitatory and inhibitory synaptic inputs onto the dendrites, and their distal tips provide directionally selective excitatory outputs onto ganglion cells. Detailed simulations of putative cells support this model, given reasonable parameter constraints. The performance of the model also suggests that this computational substructure may be relevant within the dendritic trees of CNS neurons in general.en_US
dc.format.extent148 p.en_US
dc.format.extent12400547 bytes
dc.format.extent4859569 bytes
dc.language.isoen_US
dc.subjectcomputational neuroscienceen_US
dc.subjectneural modellingen_US
dc.subjectretinaselectrophysiologyen_US
dc.titleOn Directional Selectivity in Vertebrate Retina: An Experimental and Computational Studyen_US


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