Browsing by Author "Tavare, Simon"

Now showing items 1-4 of 4

  • Data analysis issues for allele-specific expression using Illumina's GoldenGate assay 

    Ritchie, Matthew E; Forrest, Matthew S; Dimas, Antigone S; Daelemans, Caroline; Dermitzakis, Emmanouil T; Deloukas, Panagiotis; Tavare, Simon (2010-05-26)
    Abstract Background High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use ...

  • High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta 

    Daelemans, Caroline; Ritchie, Matthew E; Smits, Guillaume; Abu-Amero, Sayeda; Sudbery, Ian M; Forrest, Matthew S; Campino, Susana; Clark, Taane G; Stanier, Philip; Kwiatkowski, Dominic; Deloukas, Panos; Dermitzakis, Emmanouil T; Tavare, Simon; Moore, Gudrun E; Dunham, Ian (2010-04-19)
    Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...

  • Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes 

    Curtis, Christina; Landis, Gary N; Folk, Donna; Wehr, Nancy B; Hoe, Nicholas; Waskar, Morris; Abdueva, Diana; Skvortsov, Dmitriy; Ford, Daniel; Luu, Allan; Badrinath, Ananth; Levine, Rodney L; Bradley, Timothy J; Tavare, Simon; Tower, John (2007-12-09)
    Abstract Background Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and ...

  • Using expression arrays for copy number detection: an example from E. Coli 

    Skvortsov, Dmitriy; Abdueva, Diana; Stitzer, Michael E; Finkel, Steven E; Tavare, Simon (2007-06-14)
    Abstract Background The sequencing of many genomes and tiling arrays consisting of millions of DNA segments spanning entire genomes have made high-resolution copy number analysis possible. Microarray-based comparative ...