Molecular Dynamics Simulation Of Transport Of  Encapsulated Drug Through A Lipid Bilayer

dc.contributor.author	Ibrahim, Buba Gaba
dc.date.accessioned	2015-08-05T15:37:50Z
dc.date.available	2015-08-05T15:37:50Z
dc.date.issued	2014-12-15
dc.identifier.uri	http://repository.aust.edu.ng/xmlui/handle/123456789/275
dc.identifier.uri	http://library.aust.edu.ng:8080/xmlui/handle/123456789/275
dc.description.abstract	Most anticancer drugs are polar, cytotoxic and have complicated structures which cause difficulty in their penetration through the cell membrane. This presents a serious problem in chemotherapy. Is it possible to use carbon nanotubes (CNTs) as intracellular drug delivery agents to concomitantly mininmize side effects and maximize therapeutic effect? Although previous experimental and simulation studies have demonstrated that CNTs are able to translocate through cell membrane, the cell penetration mechanisms are not well understood. In this study, we used molecular dynamics simulation to examine the trans- port of an anticancer drug, Cisplatin, (with and without encapsulation in a CNT) across a solvated DPPC (1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE) lipid bilayer which represents the cell membrane.	en_US
dc.language.iso	en	en_US
dc.subject	Ibrahim, Buba Gaba	en_US
dc.subject	2014	en_US
dc.subject	Molecular Dynamics Simulation Of Transport Of Encapsulated Drug Through A Lipid Bilayer	en_US
dc.subject	Theoretical Physics	en_US
dc.subject	Omololu Akin-Ojo	en_US
dc.title	Molecular Dynamics Simulation Of Transport Of Encapsulated Drug Through A Lipid Bilayer	en_US
dc.type	Thesis	en_US