Abstract Background The sequencing of many genomes and tiling arrays consisting of millions of DNA segments spanning entire genomes have made high-resolution copy number analysis possible. Microarray-based comparative ...

This thesis is concerned with the fluid mechanics of floating and sinking. More specifically, the majority of this thesis considers the role played by surface tension in allowing dense objects to float. We first derive ...

This thesis considers linear perturbations to the steady flow of a compressible inviscid perfect gas along a cylindrical or annular duct. Particular consideration is given to the model of the duct boundary, and to the ...

Abstract Background Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and ...

Hadrons containing heavy quarks, in particular b quarks, play an important role in high energy physics. Measurements of their electroweak interactions are used to test the Standard Model and search for new physics. For ...

Rayleigh-Taylor instability has been an area of active research in fluid dynamics for the last twenty years, but relatively little attention has been paid to the dynamics of problems where Rayleigh-Taylor instability ...

This thesis: (a) presents the solution of several boundary value problems (BVPs) for the Laplace and the modified Helmholtz equations in the interior of an equilateral triangle; (b) presents the solution of the heat ...

Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...

The ultimate goal of this thesis is to improve our understanding of the cosmology of axions. Axions couple to QCD instantons and these non-perturbative effects are modeled within the framework of the interacting instanton ...

The aims of this thesis are to develop and validate a robust and efficient algorithm for the numerical solution of the equations of General Relativistic Hydrodynamics, to implement the algorithm in a computationally efficient ...

Abstract Background High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use ...

This thesis presents methods for efficient numerical approximation of linear and non-linear systems of highly oscillatory ordinary differential equations. Phenomena of high oscillation is considered a major computational ...

Accretion discs are fluid-dynamical entities which surround many black holes. Observations reveal that these systems exhibit variability on a range of time scales. This thesis investigates phenomena occurring in black-hole ...

We consider the stability of black holes within both classical general relativity and the semiclassical thermodynamic description. In particular, we study linearised perturbations and their contribution to the gravitational ...