Browsing Department of Materials Science and Metallurgy by Author "Charlesworth, Paul"

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A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks

Cotterill, Ellese; Charlesworth, Paul; Thomas, Christopher W; Paulsen, Ole; Eglen, Stephen John (American Physiological SocietyJournal of Neurophysiology, 2016-04-20)

Accurate identification of bursting activity is an essential element in the characterization of neuronal network activity. Despite this, no one technique for identifying bursts in spike trains has been widely adopted. ...
Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures

Charlesworth, Paul; Cotterill, Ellese; Morton, Andrew; Grant, Seth GN; Eglen, Stephen John (SpringerNeural Development, 2015-01-28)

Background: Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had ...