dc.creator | Hjorth, JJ Johannes | |
dc.creator | Sterratt, David C | |
dc.creator | Cutts, Catherine S | |
dc.creator | Willshaw, David J | |
dc.creator | Eglen, Stephen John | |
dc.date.accessioned | 2014-10-28 | |
dc.date.accessioned | 2018-11-24T23:17:53Z | |
dc.date.available | 2014-11-19T15:18:02Z | |
dc.date.available | 2018-11-24T23:17:53Z | |
dc.date.issued | 2014-11-14 | |
dc.identifier | https://www.repository.cam.ac.uk/handle/1810/246408 | |
dc.identifier.uri | http://repository.aust.edu.ng/xmlui/handle/123456789/3185 | |
dc.description.abstract | Molecular and activity-based cues
acting together are thought to guide retinal axons to their
terminal sites in vertebrate optic tectum or superior colliculus
(SC) to form an ordered map of connections. The
details of mechanisms involved, and the degree to which
they might interact, are still not well understood. We
have developed a framework within which existing computational
models can be assessed in an unbiased and
quantitative manner against a set of experimental data
curated from the mouse retinocollicular system. Our
framework facilitates comparison between models, testing
new models against known phenotypes and simulating
new phenotypes in existing models.We have used this
framework to assess four representative models that
combine Eph/ephrin gradients and/or activity-based
mechanisms and competition. Two of the models were
updated from their original form to fit into our framework.
The models were tested against five different phenotypes:
wild type, Isl2-EphA3ki/ki, Isl2-EphA3ki/1,
ephrin-A2,A3,A5 triple knock-out (TKO), and Math52/2
(Atoh7). Two models successfully reproduced the extent
of the Math52/2 anteromedial projection, but only one of
those could account for the collapse point in Isl2-
EphA3ki/1. The models needed a weak anteroposterior
gradient in the SC to reproduce the residual order in
the ephrin-A2,A3,A5 TKO phenotype, suggesting
either an incomplete knock-out or the presence of
another guidance molecule. Our article demonstrates the
importance of testing retinotopic models against as full a
range of phenotypes as possible, and we have made available
MATLAB software, we wrote to facilitate this process. | |
dc.language | en | |
dc.publisher | Wiley | |
dc.publisher | Developmental Neurobiology | |
dc.rights | http://creativecommons.org/licenses/by/2.0/uk/ | |
dc.rights | Attribution 2.0 UK: England & Wales | |
dc.subject | mouse | |
dc.subject | retinocollicular projection | |
dc.subject | retinotopic map formation | |
dc.subject | computational modelling framework | |
dc.subject | quantitative evaluation | |
dc.title | Quantitative assessment of computational models for retinotopic map formation | |
dc.type | Article | |