Browsing by Author "Cotterill, Ellese"
Now showing items 1-4 of 4
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A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks
(American Physiological SocietyJournal of Neurophysiology, 2016-04-20)Accurate identification of bursting activity is an essential element in the characterization of neuronal network activity. Despite this, no one technique for identifying bursts in spike trains has been widely adopted. ...
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Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates
(SAGE PublicationsJournal of Biomolecular Screening, 2016-03-29)We examined neural network ontogeny using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro (DIV). In primary cortical cultures, action potential spiking activity ...
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Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures
(SpringerNeural Development, 2015-01-28)Background: Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had ...
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Statistical analysis of neuronal data: Development of quantitative frameworks and application to microelectrode array analysis and cell type classification
(University of CambridgeDAMTPTrinity, 2017-10-01)With increasing amounts of data being collected in various fields of neuroscience, there is a growing need for robust techniques for the analysis of this information. This thesis focuses on the evaluation and development ...