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Geniculo-Cortical Projection Diversity Revealed within the Mouse Visual Thalamus
(PLOSPLOS ONE, 2016-01-04)
The mouse dorsal lateral geniculate nucleus (dLGN) is an intermediary between retina and primary visual cortex (V1). Recent investigations are beginning to reveal regional complexity in mouse dLGN. Using local injections ...
Homeostatic Activity-Dependent Tuning of Recurrent Networks for Robust Propagation of Activity
(Society for NeuroscienceJournal of Neuroscience, 2016-03-30)
Developing neuronal networks display spontaneous bursts of action potentials that are necessary for circuit organization and tuning. While spontaneous activity has been shown to instruct map formation in sensory circuits, ...
Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates
(SAGE PublicationsJournal of Biomolecular Screening, 2016-03-29)
We examined neural network ontogeny using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro (DIV). In primary cortical cultures, action potential spiking activity ...
A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks
(American Physiological SocietyJournal of Neurophysiology, 2016-04-20)
Accurate identification of bursting activity is an essential element in the characterization of neuronal network activity. Despite this, no one technique for identifying bursts in spike trains has been widely adopted. ...