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The role of gene fusions in the evolution of metabolic pathways: the histidine biosynthesis case
(2007-08-16)
Abstract Background Histidine biosynthesis is one of the best characterized anabolic pathways. There is a large body of genetic and biochemical information available, including operon structure, gene expression, and ...
Modeling HIV quasispecies evolutionary dynamics
(2007-08-16)
Abstract Background During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The ...
Analysis of a finite element formulation for modelling phase separation
(Springer, 2007)
The Cahn-Hilliard equation is of importance in materials science and a range of other fields. It represents a diffuse interface model for simulating the evolution of phase separation in solids and fluids, and is a nonlinear ...
Nano-Bio-Genesis: Tracing the rise of nanotechnology and nanobiotechnology as 'big science'
(2007-07-14)
Abstract Nanotechnology research has lately been of intense interest because of its perceived potential for many diverse fields of science. Nanotechnology's tools have found application in diverse fields, from biology to ...
Ultra-fast Imaging of Two-Phase Flow in Structured Monolith Reactors; Techniques and Data Analysis
(University of CambridgeDepartment of Chemical Engineering, 2007-03)
This thesis will address the use of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) techniques to probe the “monolith reactor”, which consists of a structured catalyst over which reactions may occur. ...
A $C^0$ discontinuous Galerkin formulation for thin shells
(2007)
This paper presents a C 0 discontinuous Galerkin formulation for the simulation of thin shells. The method is based on Koiter’s shell model and allows finite element solutions to be obtained by using standard $C^0$ Lagrange ...
Model-based approaches to support process improvement in complex product development
(University of CambridgeDepartment of Engineering, 2007-10-23)
The performance of product development processes is important to the commercial success of new products. The improvement of these processes is thus a strategic imperative for many engineering companies — the aero-engine ...
Modelling iteration in engineering design
(16th International Conference on Engineering Design (ICED'07)16th International Conference on Engineering Design (ICED'07), 2007-08-28)
This paper examines design iteration and its modelling in the simulation of New Product Development (NPD) processes. A framework comprising six perspectives of iteration is proposed and it is argued that the importance of ...
Experimental behavior of reinforced concrete beams strengthened with prestressed CFRP shear straps
(American Society of Civil EngineersJournal of Composites for Construction (ASCE), 2007)
One promising means of increasing the capacity of existing shear-deficient beams is to strengthen the structure using external prestressed carbon fiber reinforced polymer (CFRP) straps. In this system, layers of CFRP tape ...
Supporting design planning through process model simulation
(University of CambridgeChurchill CollegeDepartment of Engineering, 2007-02-13)
Modelling and analysis of design processes is non-trivial and predicting the behaviour
of such systems is especially challenging. Nonetheless, the effective planning of design projects is critical for many engineering ...