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Molecular Dynamics Simulation Of Transport Of Encapsulated Drug Through A Lipid Bilayer

dc.contributor.authorIbrahim, Buba Gaba
dc.date.accessioned2015-08-05T15:37:50Z
dc.date.available2015-08-05T15:37:50Z
dc.date.issued2014-12-15
dc.identifier.urihttp://repository.aust.edu.ng/xmlui/handle/123456789/275
dc.identifier.urihttp://library.aust.edu.ng:8080/xmlui/handle/123456789/275
dc.description.abstractMost anticancer drugs are polar, cytotoxic and have complicated structures which cause difficulty in their penetration through the cell membrane. This presents a serious problem in chemotherapy. Is it possible to use carbon nanotubes (CNTs) as intracellular drug delivery agents to concomitantly mininmize side effects and maximize therapeutic effect? Although previous experimental and simulation studies have demonstrated that CNTs are able to translocate through cell membrane, the cell penetration mechanisms are not well understood. In this study, we used molecular dynamics simulation to examine the trans- port of an anticancer drug, Cisplatin, (with and without encapsulation in a CNT) across a solvated DPPC (1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE) lipid bilayer which represents the cell membrane.en_US
dc.language.isoenen_US
dc.subjectIbrahim, Buba Gabaen_US
dc.subject2014en_US
dc.subjectMolecular Dynamics Simulation Of Transport Of Encapsulated Drug Through A Lipid Bilayeren_US
dc.subjectTheoretical Physicsen_US
dc.subjectOmololu Akin-Ojoen_US
dc.titleMolecular Dynamics Simulation Of Transport Of Encapsulated Drug Through A Lipid Bilayeren_US
dc.typeThesisen_US


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    Electronic Theses from Department of Theoretical Physics

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