Browsing Department of Materials Science and Metallurgy by Author "Eglen, Stephen John"
Now showing items 1-11 of 11
-
A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks
(American Physiological SocietyJournal of Neurophysiology, 2016-04-20)Accurate identification of bursting activity is an essential element in the characterization of neuronal network activity. Despite this, no one technique for identifying bursts in spike trains has been widely adopted. ...
-
A molecular mechanism for the topographic alignment of convergent neural maps
(eLife Sciences Publications LtdeLife, 2017-03-14)Sensory processing requires proper alignment of neural maps throughout the brain. In the superficial layers of the superior colliculus of the midbrain, converging projections from retinal ganglion cells and neurons in ...
-
Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates
(SAGE PublicationsJournal of Biomolecular Screening, 2016-03-29)We examined neural network ontogeny using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro (DIV). In primary cortical cultures, action potential spiking activity ...
-
Detecting pairwise correlations in spike trains: an objective comparison of methods and application to the study of retinal waves
(Society for NeuroscienceJournal of Neuroscience, 2014-10-22)Correlations in neuronal spike times are thought to be key to processing in many neural systems. Many measures have been proposed to summarize these correlations and of these the correlation index is widely used and is the ...
-
Editorial: Understanding neural organization using statistical analysis and computational modelling: from single cells to large-scale networks
(FrontiersFrontiers in Neuroanatomy, 2015-10-26)
-
Estimating the location and size of retinal injections from orthogonal images of an intact retina
(BioMed CentralBMC Neuroscience, 2015-11-21)Background : To study the mapping from the retina to the brain, typically a small region of the retina is injected with a dye, which then propagates to the retina's target structures. To determine the location of the ...
-
Geniculo-Cortical Projection Diversity Revealed within the Mouse Visual Thalamus
(PLOSPLOS ONE, 2016-01-04)The mouse dorsal lateral geniculate nucleus (dLGN) is an intermediary between retina and primary visual cortex (V1). Recent investigations are beginning to reveal regional complexity in mouse dLGN. Using local injections ...
-
Homeostatic Activity-Dependent Tuning of Recurrent Networks for Robust Propagation of Activity
(Society for NeuroscienceJournal of Neuroscience, 2016-03-30)Developing neuronal networks display spontaneous bursts of action potentials that are necessary for circuit organization and tuning. While spontaneous activity has been shown to instruct map formation in sensory circuits, ...
-
Quantitative assessment of computational models for retinotopic map formation
(WileyDevelopmental Neurobiology, 2014-11-14)Molecular and activity-based cues acting together are thought to guide retinal axons to their terminal sites in vertebrate optic tectum or superior colliculus (SC) to form an ordered map of connections. The details of ...
-
Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures
(SpringerNeural Development, 2015-01-28)Background: Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had ...
-
Toward standard practices for sharing computer code and programs in neuroscience
Computational techniques are central in many areas of neuroscience and are relatively easy to share. This paper describes why computer programs underlying scientific publications should be shared and lists simple steps for ...