Department of Materials Science and Metallurgy: Recent submissions

Now showing items 641-648 of 648

  • Quantitative assessment of computational models for retinotopic map formation 

    Hjorth, JJ Johannes; Sterratt, David C; Cutts, Catherine S; Willshaw, David J; Eglen, Stephen John (WileyDevelopmental Neurobiology, 2014-11-14)
    Molecular and activity-based cues acting together are thought to guide retinal axons to their terminal sites in vertebrate optic tectum or superior colliculus (SC) to form an ordered map of connections. The details of ...

  • Local varying-alpha theories 

    Barrow, John David; Magueijo, João (World Scientific PublishingModern Physics Letters A, 2015-07-20)
    In a recent paper, we demonstrated how the simplest model for varying-alpha may be interpreted as the effect of a dielectric material, generalized to be consistent with Lorentz invariance. Unlike normal dielectrics, such ...

  • Variable selection with error control: Another look at Stability Selection 

    Shah, Rajen Dinesh; Samworth, Richard John (Wiley on behalf of the Royal Statistical SocietyJournal of the Royal Statistical Society: Series B (Statistical Methodology), 2012-06-21)
    Stability Selection was recently introduced by Meinshausen and B¨uhlmann (2010) as a very general technique designed to improve the performance of a variable selection algorithm. It is based on aggregating the results of ...

  • Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer 

    Satheesha, Sampoorna; Cookson, Victoria J; Coleman, Louise J; Ingram, Nicola; Madhok, Brijesh; Hanby, Andrew M; Suleman, Charlotte AB; Sabine, Vicky S; Macaskill, E Jane; Bartlett, John MS; Dixon, J Michael; McElwaine, James Nicholas; Hughes, Thomas A (2011-02-14)
    Abstract Background Inhibitors of the kinase mTOR, such as rapamycin and everolimus, have been used as cancer therapeutics with limited success since some tumours are resistant. Efforts to establish predictive markers to ...

  • Data analysis issues for allele-specific expression using Illumina's GoldenGate assay 

    Ritchie, Matthew E; Forrest, Matthew S; Dimas, Antigone S; Daelemans, Caroline; Dermitzakis, Emmanouil T; Deloukas, Panagiotis; Tavare, Simon (2010-05-26)
    Abstract Background High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use ...

  • High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta 

    Daelemans, Caroline; Ritchie, Matthew E; Smits, Guillaume; Abu-Amero, Sayeda; Sudbery, Ian M; Forrest, Matthew S; Campino, Susana; Clark, Taane G; Stanier, Philip; Kwiatkowski, Dominic; Deloukas, Panos; Dermitzakis, Emmanouil T; Tavare, Simon; Moore, Gudrun E; Dunham, Ian (2010-04-19)
    Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...

  • Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes 

    Curtis, Christina; Landis, Gary N; Folk, Donna; Wehr, Nancy B; Hoe, Nicholas; Waskar, Morris; Abdueva, Diana; Skvortsov, Dmitriy; Ford, Daniel; Luu, Allan; Badrinath, Ananth; Levine, Rodney L; Bradley, Timothy J; Tavare, Simon; Tower, John (2007-12-09)
    Abstract Background Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and ...

  • Using expression arrays for copy number detection: an example from E. Coli 

    Skvortsov, Dmitriy; Abdueva, Diana; Stitzer, Michael E; Finkel, Steven E; Tavare, Simon (2007-06-14)
    Abstract Background The sequencing of many genomes and tiling arrays consisting of millions of DNA segments spanning entire genomes have made high-resolution copy number analysis possible. Microarray-based comparative ...