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The synthesis of di-carboxylate esters using continuous flow vortex fluidics

dc.creatorBritton, Joshua
dc.creatorDalziel, Stuart Bruce
dc.creatorRaston, Colin L
dc.description.abstractA vortex fluidic device (VFD) is effective in mediating the synthesis of di-esters at room temperature. Processing under ambient conditions allows for a simple and efficient synthesis, whilst operating under continuous flow addresses scalability. The rotational speed of the sample tube and the flow rate were critical variables during reaction optimization, and this relates to the behaviour of the fluid flow at a molecular level. Whilst at specific rotational speeds the tube imparts a vibrational response into the fluid flow, the flow rate dictates residence time and the ability to maintain high levels of shear stress. The combination of mechanically induced vibrations, rapid micromixing and high levels of shear stress generate yields up to 90% for 3.25 minutes or less residence time. These results are key for devising greener and more efficient processes both mediated by the VFD and other continuous flow platforms.
dc.publisherRoyal Society of Chemistry
dc.publisherGreen Chemistry
dc.titleThe synthesis of di-carboxylate esters using continuous flow vortex fluidics

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