Cambridge University: Recent submissions
Now showing items 1241-1260 of 1268
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Device and circuit-level performance of carbon nanotube field-effect transistor with benchmarking against a nano-MOSFET
(2012-08-19)AbstractThe performance of a semiconducting carbon nanotube (CNT) is assessed and tabulated for parameters against those of a metal-oxide-semiconductor field-effect transistor (MOSFET). Both CNT and MOSFET models considered ...
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The Semantics of Chemical Markup Language (CML) for Computational Chemistry : CompChem
(2012-08-07)AbstractThis paper introduces a subdomain chemistry format for storing computational chemistry data called CompChem. It has been developed based on the design, concepts and methodologies of Chemical Markup Language (CML) ...
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Non-solvolytic synthesis of aqueous soluble TiO2 nanoparticles and real-time dynamic measurements of the nanoparticle formation
(2012-06-07)AbstractHighly aqueously dispersible (soluble) TiO2 nanoparticles are usually synthesized by a solution-based sol–gel (solvolysis/condensation) process, and no direct precipitation of titania has been reported. This ...
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The application of selective reaction monitoring shows dysregulation of glycolysis in a preclinical model of schizophrenia
(2012-03-15)Abstract Background Establishing preclinical models is essential for novel drug discovery in schizophrenia. Most existing models are characterized by abnormalities in behavioral readouts, which are informative, but do not ...
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Variable selection with error control: Another look at Stability Selection
(Wiley on behalf of the Royal Statistical SocietyJournal of the Royal Statistical Society: Series B (Statistical Methodology), 2012-06-21)Stability Selection was recently introduced by Meinshausen and B¨uhlmann (2010) as a very general technique designed to improve the performance of a variable selection algorithm. It is based on aggregating the results of ...
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Exploring subdomain variation in biomedical language
(2011-05-27)AbstractApplications of Natural Language Processing (NLP) technology to biomedical texts have generated significant interest in recent years. In this paper we identify and investigate the phenomenon of linguistic subdomain ...
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Response to: DNA identification by pedigree likelihood ratio accommodating population substructure and mutations
(2011-03-25)Abstract Mutation models are important in many areas of genetics including forensics. This letter criticizes the model of the paper 'DNA identification by pedigree likelihood ratio accommodating population substructure and ...
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A comparison and user-based evaluation of models of textual information structure in the context of cancer risk assessment
(2011-03-08)Abstract Background Many practical tasks in biomedicine require accessing specific types of information in scientific literature; e.g. information about the results or conclusions of the study in question. Several schemes ...
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Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer
(2011-02-14)Abstract Background Inhibitors of the kinase mTOR, such as rapamycin and everolimus, have been used as cancer therapeutics with limited success since some tumours are resistant. Efforts to establish predictive markers to ...
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The dynamics of the impact and coalescence of droplets on a solid surface
(Biomicrofluidics, 2011)A simple experimental setup to study the impact and coalescence of deposited droplets is described. Droplet impact and coalescence have been investigated by high-speed particle image velocimetry. Velocity fields near the ...
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Q&A: Robotics as a tool to understand the brain
(2010-07-23)
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Data analysis issues for allele-specific expression using Illumina's GoldenGate assay
(2010-05-26)Abstract Background High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use ...
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High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta
(2010-04-19)Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...
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Expression profiling and cross-species RNA interference (RNAi) of desiccation-induced transcripts in the anhydrobiotic nematode Aphelenchus avenae
(2010-01-19)Abstract Background Some organisms can survive extreme desiccation by entering a state of suspended animation known as anhydrobiosis. The free-living mycophagous nematode Aphelenchus avenae can be induced to enter anhydrobiosis ...
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Computational modeling of the EGFR network elucidates control mechanisms regulating signal dynamics
(2009-12-22)Abstract Background The epidermal growth factor receptor (EGFR) signaling pathway plays a key role in regulation of cellular growth and development. While highly studied, it is still not fully understood how the signal is ...
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The first step in the development of text mining technology for cancer risk assessment: identifying and organizing scientific evidence in risk assessment literature
(2009-09-22)Abstract Background One of the most neglected areas of biomedical Text Mining (TM) is the development of systems based on carefully assessed user needs. We have recently investigated the user needs of an important task yet ...
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BayesPeak: Bayesian analysis of ChIP-seq data
(2009-09-21)Abstract Background High-throughput sequencing technology has become popular and widely used to study protein and DNA interactions. Chromatin immunoprecipitation, followed by sequencing of the resulting samples, produces ...
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R/BHC: fast Bayesian hierarchical clustering for microarray data
(BMC Bioinformatics 2009, 2009-08-06)Abstract Background Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to ...
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Analysis of plasmid genes by phylogenetic profiling and visualization of homology relationships using Blast2Network
(2008-12-21)Abstract Background Phylogenetic methods are well-established bioinformatic tools for sequence analysis, allowing to describe the non-independencies of sequences because of their common ancestor. However, the evolutionary ...
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Calibration of an orientation sensor for freehand 3D ultrasound and its use in a hybrid acquisition system
(Biomedical Engineering OnLine, 2008-01-24)Abstract Background Freehand 3D ultrasound is a powerful imaging modality with many potential applications. However, its reliance on add-on position sensors, which can be expensive, obtrusive and difficult to calibrate, ...