Abstract Background Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and ...

Abstract Background The sequencing of many genomes and tiling arrays consisting of millions of DNA segments spanning entire genomes have made high-resolution copy number analysis possible. Microarray-based comparative ...

Abstract Background Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples available for research ...

A novel numerical technique for the modelling of interfaces is introduced for the analysis of reinforced brittle materials. The method exploits the partition of unity property of finite element shape functions. By considering ...

Abstract Background Immune dysfunction, including monocytosis and increased blood levels of interleukin-1, interleukin-6 and tumour necrosis factor α has been observed during acute episodes of major depression. These ...

Using a codimension-1 algebraic cycle obtained from the Poincar e line bundle, Beauville de ned the Fourier transform on the Chow groups of an abelian variety A and showed that the Fourier transform induces a decomposition ...

Semi-Markov models are a generalisation of Markov models that explicitly model the state-dependent sojourn time distribution, the time for which the system remains in a given state. Markov models result in an exponentially ...