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3d Printing Scaffolds for Breast Tissue Engineering Applications

dc.contributor.authorAzuka, Alex
dc.description.abstractRecently, the field of Tissue Engineering has explored the potential for the regeneration of many organs and tissues in the human body. The aim of this study applied to breast tissue engineering is to overcome the major criticalities practiced with conventional therapies (mastectomy, breast conserving therapy, and lipofilling). This Thesis is focused on the fabrication of biodegradable 3D implantable Scaffolds cultured with the breast cells for regeneration of damaged tissues. Poly Lactic Acid (PLA) is the polymer used for this study. In this work, the degradation of the 3D PLA Scaffolds immersed in Simulated Body Fluid (SBF). The mechanical properties of the scaffolds are also measured and after culturing with mammary breast cells. From the study, it was observed that the PLA scaffolds degrade over time, as the number of weeks of exposure increase. The mechanical properties before and after culturing with the breast cells showed a significant increase in their tensile strength and Young’s modulus. However, the tensile strength and elastic modulus after culturing was 3.42 and 6.10 MPa for day 0 and 7 and 234.67 and 337.33 MPa for day 0 and 7, respectively.en_US
dc.description.sponsorshipAUST and PAMIen_US
dc.subjectAlex Azukaen_US
dc.subjectProf. Wole Soboyejoen_US
dc.subjecttissue engineeringen_US
dc.subjectbreast canceren_US
dc.subjectsimulated body fluiden_US
dc.subjectpoly lactic aciden_US
dc.subjectmechanical propertiesen_US
dc.subjectYoung’s Modulusen_US
dc.subject2020 Materials Science and Engineering Thesesen_US
dc.title3d Printing Scaffolds for Breast Tissue Engineering Applicationsen_US

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