Implantable Resorbable and Non Resorbable Magnetite Nanocomposite For Localize Drug Delivery and Hyperthermia in Breast Cancer Treatment.

Abstract

The work presents the comparative studies of the potentials of the implantable magnetite nanocomposites of both resorbable and non-resorbable localized treatment of breast cancer through hyperthermia. Magnetite reinforced polydimethylsiloxane and Polycaprolactone composites were simulated. The in - vivo temperature profiles and thermal doses were investigated by the use of a 3D finite element method (FEM) model to simulate the heating of breast tissue. Heat generation was calculated using linear response theory model. The generated heat in these cases is also seen to be enough to serve as the transition temperature for the thermosensitive drug loaded hydrogel embed in the device with micro channels for release since the drug release kinematic of the gel occurs between 37deg C and 45deg C.The work also presents the mechanical failure of the materials under tension using simulations and analytical techniques. Abaqus software was used in the study, the implication of the results were then discussed for the development of implantable devices for both localized treatment of breast cancer.