Abstract Background Histidine biosynthesis is one of the best characterized anabolic pathways. There is a large body of genetic and biochemical information available, including operon structure, gene expression, and ...

Abstract Background The import of most intraperoxisomal proteins is mediated by peroxisome targeting signals at their C-termini (PTS1) or N-terminal regions (PTS2). Both signals have been integrated in subcellular location ...

Abstract Background During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The ...

Abstract Background Several diseases, many of which nowadays pandemic, consist of multifactorial pathologies. Paradigmatic examples come from the immune response to pathogens, in which cases the effects of different ...

Abstract Background Grouping genes into clusters on the basis of similarity between their expression profiles has been the main approach to predict functional modules, from which important inference or further investigation ...

Abstract In this article, direct coating of ZnO on PECVD-grown multi-walled carbon nanotubes (MWCNTs) is achieved using atomic layer deposition (ALD). Transmission electron microscopy investigation shows that the deposited ...

Abstract Background Public-private partnerships (PPPs) are potential instruments to enable private collaboration in the health sector. Despite theoretical debate, empirical analyses have thus far tended to focus on the ...

Abstract Background Improving health in our nation requires strengthening four major domains of the health care system: personal health management, health care delivery, public health, and health-related research. Many ...

Abstract Nanotechnology research has lately been of intense interest because of its perceived potential for many diverse fields of science. Nanotechnology's tools have found application in diverse fields, from biology to ...

The thesis reports on the application of advanced microanalytical techniques to answer a fundamental open question on the homeostasis of Plasmodium falciparum infected red blood cells, namely how infected cells retain their ...

Failure modes for sandwich beams of GFRP laminate skins and Nomex honeycomb core are investigated. Theoretical models using honeycomb mechanics and classical beam theory are described. A failure mode map for loading under ...

The performance of product development processes is important to the commercial success of new products. The improvement of these processes is thus a strategic imperative for many engineering companies — the aero-engine ...

The goal of this research is to develop explanation presentation mechanisms for knowledge based systems which enable them to define domain terminology and concepts, narrate events, elucidate plans, processes, or propositions ...

This thesis presents a time domain finite element method for the solution of microwave heating problems. This is the first time that this particular technique has been applied to microwave heating. It is found that the ...

Additional, discontinuous functions are added to the displacement field of standard finite elements in order to capture highly localised zones of intense straining. By embedding discontinuities within an element it is ...

A procedure is illustrated for the determination of the normal direction of a discontinuity plane within a solid finite element. Using so-called embedded discontinuities, discrete constitutive models can be applied within ...

The application of continuum constitutive laws in embedded strong discontinuity analysis is examined. By adopting a regularised discontinuity (approximating the unbounded strain field resulting from a displacement jump ...

Supporting material for the article: Maraldi, M., Wells, G. N., and Molari, L. (2011). Phase field model for coupled displacive and diffusive microstructural processes under thermal loading. Journal of the Mechanics and ...

Delamination is one of the most important failure mechanisms in laminates. Normally, it is modelled using interface elements. These elements are placed between two layers that are modelled with continuum elements. The ...

Intense research efforts have been put in the formulation of theories for crack initiation and propagation in concrete. Yet, little attention has been paid to the time-dependence of fracture, despite evidence of its ...