Active shape model segmentation of Brain structures in MR images of subjects with fetal alcohol spectrum disorder

Abstract

Fetal Alcohol Spectrum Disorder (FASD) is the most common form of preventable mental retardation worldwide. This condition affects children whose mothers excessively consume alcohol whilst pregnant. FASD can be identified by physical and mental defects, such as stunted growth, facial deformities, cognitive impairment, and behavioural abnormalities. Magnetic Resonance Imaging provides a non-invasive means to study the neural correlates of FASD. One such approach aims to detect brain abnormalities through an assessment of volume and shape of sub-cortical structures on high-resolution MR images.