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Molecular Dynamics Simulation of Transport of Encapsulated Drug Through a Lipid Bilayer

dc.contributor.authorIbrahim, Buba
dc.description.abstractMost anticancer drugs are polar, cytotoxic and have complicated structures which cause difficulty in their penetration through the cell membrane. This presents a serious problem in chemotherapy. Is it possible to use carbon nanotubes (CNTs) as intracellular drug delivery agents to concomitantly mininmize side effects and maximize therapeutic effect? Although previous experimental and simulation studies have demonstrated that CNTs are able to translocate through cell membrane, the cell penetration mechanisms are not well understood. In this study, we used molecular dynamics simulation to examine the transport of an anticancer drug, Cisplatin, (with and without encapsulation in a CNT) across a solvated DPPC (1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE) lipid bilayer which represents the cell membrane.en_US
dc.subjectIbrahim Bubaen_US
dc.subjectDr Akin-Ojo Omololuen_US
dc.subject2014 Theoretical Physics Thesesen_US
dc.subjectMolecular Dynamics Simulationen_US
dc.subjectEncapsulated Drugen_US
dc.subjectLipid Bilayeren_US
dc.titleMolecular Dynamics Simulation of Transport of Encapsulated Drug Through a Lipid Bilayeren_US

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  • Theoretical and Applied Physics52

    This collection contains selected research work by Theoretical and Applied Physics Students at the master's level, from 2009-2022.

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